Monitoring, Design and Optimization of Bioprocesses
Quantitative Analysis of Metabolic and Regulatory Networks of Cellular Systems
Many products for the pharmaceutical and food
industry are nowadays produced by biotechnological
processes, replacing more and more existing
chemical processes. Ideas for inovative products
and new ways for their production on a small scale
have to be transformed into complete processes at
a large scale. Production costs, working volume,
effective scale-up, product yield, waste,
downstream processing and many other points
have to be optimized before this process will be
used in industry.
We focus on the optimization and scale-up of
bioprocesses on different levels. Process
parameters, growth conditions, medium design as well as
high cell density are of interest on the process
level, whereas cellular aspects and proteomics
are also considered.
Small scale bioreactors for parallel cultivations
Bioprocesses that are currently looked at are mainly virus production processes for influenza virus and modified vaccinia virus Ankara (MVA) focussing on vaccine production and possible gene therapy options. Therefore, cultivations of adherent as well as suspension cells are evaluated.
A process for the production of a recombinant protein (alpha-1-antitrypsin) is especially used for research on cellular metabolism.